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Manaus vs Iquitos - which is better?
They are the top two tourism gateway cities in the Amazon. Manaus is in Brazil, Iquitos is far upstream in Peru.

I've been to both. Iquitos easily wins. The Amazon river there is substantially narrower - and the tributaries are more remote, eco-diverse, and interesting. But this is not to say that the Manaus area isn't captivating. It is.

Iquitos
A few basics
AmazonManaus
A few basics
When to go
Mid-May to mid-November is the dry and best season. It can rain heavily during the rest of the year. Downpours make jungle excursion walks mud-messy.

Untold truths
The "third" Amazon
Ecuador has eco-lodges on the Rio Napo, an Amazon River tributary. But there is no worth-mentioning cruise presence.

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